LMPD Database


UniProt Annotations

Entry Information
Gene NameUDP glycosyltransferase 8
Protein EntryCGT_HUMAN
UniProt IDQ16880
Comment typeDescription
Catalytic ActivityUDP-alpha-D-galactose + 2-(2- hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2- hydroxyacyl)sphingosine.
FunctionCatalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system.
PathwaySphingolipid metabolism; galactosylceramide biosynthesis.
SimilarityBelongs to the UDP-glycosyltransferase family.
Subcellular LocationMembrane ; Single-pass membrane protein .
Web ResourceName=Functional Glycomics Gateway - GTase; Note=2- hydroxyacylsphingosine 1-beta-galactosyltransferase precursor; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_449";