LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP002485

UniProt Annotations

Entry Information
Gene Nameprohibitin 2
Protein EntryQ99623_HUMAN
UniProt IDQ99623
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99623-1; Sequence=Displayed; Name=2; IsoId=Q99623-2; Sequence=VSP_045311;
Developmental StageLevels of expression in fibroblasts decrease heterogeneously during cellular aging.
FunctionActs as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging. {ECO
InductionExpression increases approximately 3-fold upon entry into G1 phase compared to other phases of the cell cycle. Also induced following inhibition of mitochondrial protein synthesis by thiamphenicol.
InteractionP03372:ESR1; NbExp=4; IntAct=EBI-358348, EBI-78473;
SimilarityBelongs to the prohibitin family.
Subcellular LocationMitochondrion inner membrane . Cytoplasm {ECO
SubunitInteracts with PHB, ESR1, HDAC1 and HDAC5 (By similarity). Interacts with ZNF703. Interacts with STOML2. {ECO