| Comment type | Description |
|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=3; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q9Y371-1; Sequence=Displayed; Name=2; IsoId=Q9Y371-2; Sequence=VSP_009276; Name=3; IsoId=Q9Y371-3; Sequence=VSP_044895; Note=No experimental confirmation available.; |
| Caution | It is uncertain whether Met-1 or Met-4 is the initiator. |
| Caution | Was originally thought to have lysophosphatidic acid acyltransferase activity, but by homology with SH3GL2/endophilin A1 is unlikely to have this activity. |
| Domain | An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes. |
| Function | May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. {ECO |
| Interaction | Self; NbExp=4; IntAct=EBI-2623095, EBI-2623095; Q07812:BAX; NbExp=2; IntAct=EBI-5291808, EBI-516580; P24522:GADD45A; NbExp=2; IntAct=EBI-2623095, EBI-448167; Q9NR46:SH3GLB2; NbExp=5; IntAct=EBI-2623095, EBI-749607; Q9P2Y5:UVRAG; NbExp=2; IntAct=EBI-2623095, EBI-2952704; |
| Miscellaneous | HeLa cells lacking SH3GLB1 show dissociation of outer and inner mitochondrial membrane as well as abnormal mitochondrial morphology. Cells overexpressing SH3GLB1 lacking an N-terminal amphipathic helix show a similar phenotype. |
| Miscellaneous | SH3GLB1 binds liposomes and induces formation of tubules from liposomes. SH3GLB1 lacking the N-terminal amphipathic helix fails to induce liposome tubulation. |
| Ptm | Phosphorylated at Thr-145 by CDK5; this phosphorylation is required for autophagy induction in starved neurons and facilitates homodimerization. |
| Sequence Caution | Sequence=AAF81225.1; Type=Erroneous initiation; Evidence= ; Sequence=BAD88797.1; Type=Erroneous initiation; Evidence= ; |
| Similarity | Belongs to the endophilin family. |
| Similarity | Contains 1 BAR domain. {ECO |
| Similarity | Contains 1 SH3 domain. {ECO |
| Subcellular Location | Cytoplasm . Golgi apparatus membrane ; Peripheral membrane protein . Mitochondrion outer membrane ; Peripheral membrane protein . Note=Association with the Golgi apparatus depends on the cell type. |
| Subunit | Binds DNM1, HTT, AMPH, BIN1 and ARFGAP1 (By similarity). Homodimer, and heterodimer with SH3GLB2. Binds BAX. Induction of apoptosis augments BAX binding. |
| Tissue Specificity | Highly expressed in heart, skeletal muscle, kidney and placenta. Detected at lower levels in brain, colon, thymus, spleen, liver, small intestine, lung and peripheral blood leukocytes. {ECO |