LMPD Database

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LMP002483

UniProt Annotations

Entry Information
Gene Namemediator complex subunit 16
Protein EntryQ9Y2X0_HUMAN
UniProt IDQ9Y2X0
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1 ; IsoId=Q9Y2X0-1; Sequence=Displayed; Name=2 ; IsoId=Q9Y2X0-2; Sequence=VSP_051724; Name=3 ; IsoId=Q9Y2X0-3; Sequence=VSP_051722, VSP_051724; Note=No experimental confirmation available. ; Name=4 ; IsoId=Q9Y2X0-4; Sequence=VSP_051721, VSP_051723; Note=No experimental confirmation available. ; Name=5; IsoId=Q9Y2X0-5; Sequence=VSP_028749, VSP_028750; Note=No experimental confirmation available.;
CautionIt is uncertain whether Met-1 or Met-13 is the initiator.
FunctionComponent of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO
Sequence CautionSequence=AAD31087.1; Type=Frameshift; Positions=609; Evidence= ;
SimilarityBelongs to the Mediator complex subunit 16 family.
SimilarityContains 5 WD repeats. {ECO
Subcellular LocationNucleus .
SubunitComponent of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. {ECO