LMPD Database

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LMP002478

UniProt Annotations

Entry Information
Gene Namelysophosphatidic acid receptor 1
Protein EntryLPAR1_MOUSE
UniProt IDP61793
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P61793-1, Q61130-1; Sequence=Displayed; Name=2; IsoId=P61793-2, Q61130-2; Sequence=VSP_001986;
FunctionReceptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation (By similarity). {ECO:0000250}.
InteractionQ9NZN5:ARHGEF12 (xeno); NbExp=3; IntAct=EBI-7512335, EBI-821440;
SimilarityBelongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular LocationCell surface {ECO:0000250}. Cell membrane; Multi-pass membrane protein. Note=Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA co- localizes with RALA in the endocytic vesicles. {ECO:0000250}.
SubunitInteracts with RALA and ADRBK1. {ECO:0000250}.
Tissue SpecificityExpressed within the embryonic cerebral cortex, where it is enriched in the ventricular zone. In the adult brain, also expressed in oligodendrocytes, as well as Schwann cells of the peripheral nervous system. Expressed in many other tissues, including testes, lung, heart, intestine, spleen, kidney, thymus, and stomach. No expression in liver.