LMPD Database

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LMP002465

UniProt Annotations

Entry Information
Gene Namepleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2
Protein EntryPKHA2_MOUSE
UniProt IDQ9ERS5
SpeciesMouse
Comments
Comment typeDescription
FunctionBinds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane. {ECO:0000269|PubMed:12101241, ECO:0000269|PubMed:14516276}.
InteractionO75970:MPDZ (xeno); NbExp=5; IntAct=EBI-8079166, EBI-821405;
SimilarityContains 2 PH domains. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:12101241}. Cell membrane {ECO:0000269|PubMed:12101241}; Peripheral membrane protein {ECO:0000269|PubMed:12101241}. Nucleus {ECO:0000269|PubMed:12101241}. Note=Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2.
SubunitBinds MPDZ and PTPN13.