LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP002464

UniProt Annotations

Entry Information
Gene Namepleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 3
Protein EntryPKHA3_MOUSE
UniProt IDQ9ERS4
SpeciesMouse
Comments
Comment typeDescription
DomainThe PH domain of FAPPS binds the small GTPase ARF1 and phosphatidylinositol-4-phosphate (PtdIns4P) with high selectivity, and is required for recruitment of FAPPs to the trans-Golgi network (TGN). {ECO:0000250}.
FunctionInvolved in Golgi to cell surface membrane traffic. Induces membrane tubulation. Binds preferentially to phosphatidylinositol 4-phosphate (PtdIns4P) (By similarity). {ECO:0000250}.
SimilarityContains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Subcellular LocationGolgi apparatus, trans-Golgi network membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
SubunitInteracts with GTP-bound ARF1. {ECO:0000250}.