LMPD Database

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LMP002440

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 19, subfamily a, polypeptide 1
Protein EntryCP19A_MOUSE
UniProt IDP28649
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityAndrost-4-ene-3,17-dione + 3 O(2) + 3 reduced flavoproteins = estrone + formate + 4 H(2)O + 3 oxidized flavoproteins.
Catalytic ActivityTestosterone + 3 O(2) + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H(2)O + 3 oxidized flavoproteins.
CofactorName=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
FunctionCatalyzes the formation of aromatic C18 estrogens from C19 androgens.
SimilarityBelongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular LocationMembrane; Peripheral membrane protein.