LMPD Database

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LMP002399

UniProt Annotations

Entry Information
Gene Namegloboside alpha-1,3-N-acetylgalactosaminyltransferase 1
Protein EntryGBGT1_MOUSE
UniProt IDQ8VI38
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityUDP-N-acetyl-alpha-D-galactosamine + N-acetyl- D-galactosaminyl-(1->3)-D-galactosyl-(1->4)-D-galactosyl-(1->4)-D- glucosyl-(1<->1)-ceramide = UDP + N-acetyl-D-galactosaminyl- (1->3)-N-acetyl-D-galactosaminyl-(1->3)-D-galactosyl-(1->4)-D- galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide.
CofactorName=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
DomainThe conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis (By similarity). {ECO:0000250}.
FunctionCatalyzes the formation of Forssman glycolipid via the addition of N-acetylgalactosamine (GalNAc) in alpha-1,3-linkage to GalNAcb-1,3Gala-1,4Galb-1,4GlcCer (Gb4Cer). Forssman glycolipid (also called Forssman antigen; FG) probably serves for adherence of some pathogens. Conversely, it diminishes Shiga toxins susceptibility. {ECO:0000269|PubMed:14573676}.
PathwayProtein modification; protein glycosylation.
SimilarityBelongs to the glycosyltransferase 6 family. {ECO:0000305}.
Subcellular LocationGolgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Web ResourceName=Functional Glycomics Gateway - GTase; Note=Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1; URL="http://www.functionalglycomics.org/glycomics/search/jsp/landing.jsp?query=gt_mou_504";