LMPD Database

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LMP002356

UniProt Annotations

Entry Information
Gene Namedihydrolipoamide branched chain transacylase E2
Protein EntryODB2_MOUSE
UniProt IDP53395
SpeciesMouse
Comments
Comment typeDescription
Catalytic Activity2-methylpropanoyl-CoA + enzyme N(6)- (dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-(2- methylpropanoyl)dihydrolipoyl)lysine.
CofactorName=(R)-lipoate; Xref=ChEBI:CHEBI:83088; Evidence={ECO:0000250}; Note=Binds 1 lipoyl cofactor covalently. {ECO:0000250};
FunctionThe branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component.
SimilarityBelongs to the 2-oxoacid dehydrogenase family. {ECO:0000305}.
SimilarityContains 1 lipoyl-binding domain. {ECO:0000255|PROSITE-ProRule:PRU01066, ECO:0000305}.
Subcellular LocationMitochondrion matrix.
SubunitForms a 24-polypeptide structural core with octahedral symmetry.