LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP002355

UniProt Annotations

Entry Information
Gene Nameperilipin 1
Protein EntryPLIN1_MOUSE
UniProt IDQ8CGN5
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Peri A; IsoId=Q8CGN5-1; Sequence=Displayed; Name=2; Synonyms=Peri B; IsoId=Q8CGN5-2; Sequence=VSP_038208, VSP_038209; Name=3; Synonyms=Peri C; IsoId=Q8CGN5-3; Sequence=VSP_038206, VSP_038207; Name=4; Synonyms=Peri D; IsoId=Q8CGN5-4; Sequence=VSP_038204, VSP_038205;
FunctionModulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone- sensitive lipase (HSL). Its absence may result in leanness (By similarity). Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. {ECO:0000250, ECO:0000269|PubMed:23481402}.
PtmMajor cAMP-dependent protein kinase-substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL and when unphosphorylated, may play a role in the inhibition of lipolysis, by acting as a barrier in lipid droplet (By similarity). {ECO:0000250}.
SimilarityBelongs to the perilipin family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum {ECO:0000250}. Lipid droplet {ECO:0000269|PubMed:23481402}. Note=Lipid droplet surface- associated.
SubunitInteracts with ABHD5. Interacts with CIDEC. {ECO:0000269|PubMed:15292255, ECO:0000269|PubMed:23481402}.
Web ResourceName=Protein Spotlight; Note=Fat, wonderful fat - Issue 10 of May 2001; URL="http://web.expasy.org/spotlight/back_issues/010";