LMPD Database

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LMP002327

UniProt Annotations

Entry Information
Gene Namephospholipid scramblase 4
Protein EntryPLS4_HUMAN
UniProt IDQ9NRQ2
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NRQ2-1; Sequence=Displayed; Name=2; IsoId=Q9NRQ2-2; Sequence=VSP_042931, VSP_042932; Note=No experimental confirmation available.;
CofactorName=Ca(2+); Xref=ChEBI
DomainThe N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.
FunctionMay mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
InteractionP09022:Hoxa1 (xeno); NbExp=4; IntAct=EBI-769257, EBI-3957603;
Sequence CautionSequence=AAP97186.1; Type=Frameshift; Positions=152, 155, 163, 325; Evidence= ;
SimilarityBelongs to the phospholipid scramblase family.
Subcellular LocationMembrane ; Single-pass type II membrane protein .
SubunitInteracts with PDCD6.
Tissue SpecificityExpressed in heart, brain, placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, uterus, small intestine and colon. Not detected in peripheral blood lymphocytes.