LMPD Database

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LMP002321

UniProt Annotations

Entry Information
Gene Nameretinol dehydrogenase 12
Protein EntryRDH12_MOUSE
UniProt IDQ8BYK4
SpeciesMouse
Comments
Comment typeDescription
FunctionExhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected. Might be the key enzyme in the formation of 11-cis-retinal from 11-cis-retinol during regeneration of the cone visual pigments (By similarity). {ECO:0000250}.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.