LMPD Database

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LMP002312

UniProt Annotations

Entry Information
Gene Namemicrosomal triglyceride transfer protein
Protein EntryB7Z7X3_HUMAN
UniProt IDP55157
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P55157-1; Sequence=Displayed; Name=2; IsoId=P55157-2; Sequence=VSP_056325, VSP_056326; Note=No experimental confirmation available.;
DiseaseAbetalipoproteinemia (ABL) [MIM
FunctionCatalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B.
InductionPositively regulated by cholesterol and negatively regulated by insulin.
SimilarityContains 1 vitellogenin domain. {ECO
Subcellular LocationEndoplasmic reticulum.
SubunitHeterodimer composed of MTTP and of protein disulfide isomerase (P4HB/PDI).
Tissue SpecificityLiver and small intestine. Also found in ovary, testis and kidney.