LMPD Database

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LMP002309

UniProt Annotations

Entry Information
Gene NameG protein-coupled receptor 68
Protein EntryOGR1_MOUSE
UniProt IDQ8BFQ3
SpeciesMouse
Comments
Comment typeDescription
Disruption PhenotypeMice have reduced osteoclasts derived from bone marrow cells, a pH-dependent osteoclast survival effect is also detected. However, the overall bone structures of the mice are not affected. In addition melanoma cell tumorigenesis is significantly inhibited. {ECO:0000269|PubMed:19479052}.
FunctionProton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer. {ECO:0000269|PubMed:17728215, ECO:0000269|PubMed:18847331}.
Sequence CautionSequence=AAI18035.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI18045.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC29521.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC39863.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAE33483.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular LocationCell membrane; Multi-pass membrane protein.
Tissue SpecificityExpressed in the lung, testis, heart, brain, spleen, thymus, brown fat, small intestine, colon, peripheral blood leukocytes, macrophages, stomach, ovary and white fat but not in the liver, kidney, and skeletal muscle. Expression in the prostate is weak but detectable. {ECO:0000269|PubMed:19479052}.