LMPD Database

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LMP002255

UniProt Annotations

Entry Information
Gene Nameleukotriene B4 receptor
Protein EntryLT4R1_HUMAN
UniProt IDQ15722
SpeciesHuman
Comments
Comment typeDescription
FunctionReceptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.
PtmPhosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization.
Sequence CautionSequence=AAB16747.1; Type=Erroneous initiation; Evidence= ;
SimilarityBelongs to the G-protein coupled receptor 1 family.
Subcellular LocationCell membrane; Multi-pass membrane protein.
Tissue SpecificityExpressed at highest levels in heart, skeletal muscle and at lower levels in brain and liver. High level of expression in lymphoid tissues.