LMPD Database

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LMP002249

UniProt Annotations

Entry Information
Gene Nameaminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
Protein EntryADPPT_HUMAN
UniProt IDQ9NRN7
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NRN7-1; Sequence=Displayed; Name=2; IsoId=Q9NRN7-2; Sequence=VSP_055783, VSP_055784; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=0.44 mM for magnesium ; KM=0.025 mM for coenzyme A ;
Catalytic ActivityCoA-[4'-phosphopantetheine] + apo-[acyl- carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl- carrier-protein].
CofactorName=Mg(2+); Xref=ChEBI
FunctionCatalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'- phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN. {ECO
Sequence CautionSequence=AAD34075.1; Type=Frameshift; Positions=34, 63; Evidence= ; Sequence=AAF86879.1; Type=Erroneous initiation; Evidence= ;
SimilarityBelongs to the P-Pant transferase superfamily. AcpS family.
Subcellular LocationCytoplasm .
SubunitMonomer. Interacts with FASN.
Tissue SpecificityDetected in heart, skeletal muscle, placenta, testis, brain, pancreas, liver and kidney.