LMPD Database

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LMP002208

UniProt Annotations

Entry Information
Gene Nameprotein kinase, AMP-activated, beta 2 non-catalytic subunit
Protein EntryAAKB2_HUMAN
UniProt IDO43741
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O43741-1; Sequence=Displayed; Name=2; IsoId=O43741-2; Sequence=VSP_055820, VSP_055821; Note=No experimental confirmation available.;
FunctionNon-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
InteractionSelf; NbExp=2; IntAct=EBI-1053424, EBI-1053424; Q13131:PRKAA1; NbExp=6; IntAct=EBI-1053424, EBI-1181405; P54619:PRKAG1; NbExp=3; IntAct=EBI-1053424, EBI-1181439;
PtmPhosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1 and ULK2; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1, ULK2 and AMPK. {ECO
SimilarityBelongs to the 5'-AMP-activated protein kinase beta subunit family.
SubunitAMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non- catalytic subunits (PRKAG1, PRKAG2 or PRKAG3).