LMPD Database

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LMP002207

UniProt Annotations

Entry Information
Gene Namefatty acid amide hydrolase
Protein EntryFAAH1_HUMAN
UniProt IDO00519
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityAnandamide + H(2)O = arachidonic acid + ethanolamine.
Catalytic ActivityOleamide + H(2)O = oleic acid + NH(3).
Enzyme RegulationInhibited by O-aryl carbamates and alpha-keto heterocytes.
FunctionDegrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates.
PolymorphismGenetic variations in FAAH can be associated with susceptibility to polysubstance abuse [MIM
SimilarityBelongs to the amidase family.
Subcellular LocationEndomembrane system ; Single-pass membrane protein . Cytoplasm, cytoskeleton . Note=Seems to be attached to intracellular membranes and a portion of the cytoskeletal network.
SubunitHomodimer.
Tissue SpecificityHighly expressed in the brain, small intestine, pancreas, skeletal muscle and testis. Also expressed in the kidney, liver, lung, placenta and prostate.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/faah/";