LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP002195

UniProt Annotations

Entry Information
Gene Namecytohesin 3
Protein EntryCYH3_HUMAN
UniProt IDO43739
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O43739-1; Sequence=Displayed; Name=2; IsoId=O43739-2; Sequence=VSP_006039;
DomainAutoinhibited by its C-terminal basic region.
DomainBinds via its PH domain to the inositol head group of phosphatidylinositol 3,4,5-trisphosphate.
FunctionPromotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. {ECO
SimilarityContains 1 PH domain. {ECO
SimilarityContains 1 SEC7 domain. {ECO
Subcellular LocationCytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Note=Translocates from the cytosol to membranes enriched in phosphatidylinositol 3,4,5-trisphosphate.
SubunitInteracts with GRASP (By similarity). Interacts with ARF6.
Tissue SpecificityAlmost absent from liver, thymus and peripheral blood lymphocytes.