LMPD Database

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LMP002188

UniProt Annotations

Entry Information
Gene Nameapolipoprotein B
Protein EntryAPOB_MOUSE
UniProt IDE9Q414
SpeciesMouse
Comments
Comment typeDescription
FunctionApolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.
PtmPalmitoylated; structural requirement for proper assembly of the hydrophobic core of the lipoprotein particle. {ECO:0000250}.
Rna EditingModified_positions=2179; Note=The stop codon (UAA) at position 2179 is created by RNA editing. Apo B-48, derived from the fully edited RNA, is produced only in the intestine and is found in chylomicrons. Apo B-48 is a shortened form of apo B-100 which lacks the LDL-receptor region. The unedited version (apo B- 100) is produced by the liver and is found in the VLDL and LDL (By similarity). {ECO:0000250};
Sequence CautionSequence=AAI41358.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI41361.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAE27983.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityContains 1 vitellogenin domain. {ECO:0000255|PROSITE- ProRule:PRU00557}.
Subcellular LocationCytoplasm {ECO:0000250}. Secreted {ECO:0000250}.
SubunitInteracts with PCSK9. {ECO:0000250}.