LMPD Database

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LMP002181

UniProt Annotations

Entry Information
Gene Namehydroxysteroid (17-beta) dehydrogenase 7
Protein EntryDHB7_MOUSE
UniProt IDO88736
SpeciesMouse
Comments
Comment typeDescription
Catalytic Activity17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
Catalytic ActivityA 3-beta-hydroxysteroid + NADP(+) = a 3- oxosteroid + NADPH.
FunctionResponsible for the reduction of the keto group on the C-3 of sterols.
PathwaySteroid biosynthesis; estrogen biosynthesis.
PathwaySteroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 5/6.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily. {ECO:0000305}.
Subcellular LocationCell membrane; Single-pass membrane protein.
Tissue SpecificityMost abundant in ovaries of pregnant animals. Present also in nonpregnant animals in ovaries, mammary gland, liver, kidney and testis.