LMPD Database

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LMP002175

UniProt Annotations

Entry Information
Gene NameG protein-coupled receptor kinase 6
Protein EntryQ9EP84_MOUSE
UniProt IDQ9EP84
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=GRK6A; IsoId=O70293-1; Sequence=Displayed; Name=GRK6B; IsoId=O70293-2; Sequence=VSP_004939;
Catalytic ActivityATP + [G-protein-coupled receptor] = ADP + [G- protein-coupled receptor] phosphate.
Disruption PhenotypeDeficient mice show significant altered central dopamine receptors regulation, deficient lymphocyte chemotaxis and increased acute inflammation and neutrophil chemotaxis. {ECO:0000269|PubMed:12032308, ECO:0000269|PubMed:12718862, ECO:0000269|PubMed:14634128}.
FunctionSpecifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro) (By similarity). {ECO:0000250}.
InteractionQ28619:SLC9A3R1 (xeno); NbExp=5; IntAct=EBI-7073604, EBI-7073613;
SimilarityBelongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. {ECO:0000305}.
SimilarityContains 1 AGC-kinase C-terminal domain. {ECO:0000305}.
SimilarityContains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
SimilarityContains 1 RGS domain. {ECO:0000255|PROSITE- ProRule:PRU00171}.
Subcellular LocationMembrane; Lipid-anchor.
Tissue SpecificityExpressed in the brain in striatal neurons. {ECO:0000269|PubMed:12718862}.