LMPD Database

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LMP002169

UniProt Annotations

Entry Information
Gene Nameperoxisome proliferative activated receptor, gamma, coactivator 1 beta
Protein EntryPRGC2_MOUSE
UniProt IDQ8VHJ7
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VHJ7-1; Sequence=Displayed; Name=2; IsoId=Q8VHJ7-2; Sequence=VSP_019302;
DomainContains 3 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which are usually required for the association with nuclear receptors. {ECO:0000250}.
FunctionPlays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be part of the pathways regulating the elevation of gluconeogenesis, beta- oxidation of fatty acids and ketogenesis during fasting. Stimulates SREBP-mediated lipogenic gene expression in the liver. Induces energy expenditure and antagonizes obesity when overexpressed. Induces also the expression of mitochondrial genes involved in oxidative metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. {ECO:0000269|PubMed:11733490, ECO:0000269|PubMed:12678921, ECO:0000269|PubMed:14530391, ECO:0000269|PubMed:15680331}.
InductionInduced by fasting in the liver, but not by cold exposure in brown adipose tissue. Induced also by saturated fatty acids in primary hepatocytes. {ECO:0000269|PubMed:11733490, ECO:0000269|PubMed:15680331}.
MiscellaneousTransgenic mice overexpressing PPARGC1B exhibits increased expression of medium-chain acyl CoA dehydrogenase. They are hyperphagic but lean, with increased energy expenditure and resistance to obesity.
SimilarityContains 1 RRM (RNA recognition motif) domain. {ECO:0000255|PROSITE-ProRule:PRU00176}.
Subcellular LocationNucleus {ECO:0000250}.
SubunitInteracts with estrogen receptor alpha/ESR1 (By similarity). Interacts with hepatocyte nuclear factor 4- alpha/HNF4A, Sterol regulatory binding transcription factor 1/SREBF1, PPAR-alpha/PPARA, thyroid hormone receptor beta/THRB and host cell factor/HCFC1. Interacts with estrogen-related receptor gamma/ESRRG and alpha/ESRRA. Interacts with PRDM16. {ECO:0000250, ECO:0000269|PubMed:11733490, ECO:0000269|PubMed:12470660, ECO:0000269|PubMed:14530391, ECO:0000269|PubMed:15680331, ECO:0000269|PubMed:17618855, ECO:0000269|PubMed:18483224}.
Tissue SpecificityUbiquitous with higher expression in heart, brown adipose tissue, brain and skeletal muscle. {ECO:0000269|PubMed:11733490, ECO:0000269|PubMed:12678921}.