LMPD Database

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LMP002163

UniProt Annotations

Entry Information
Gene Namepleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
Protein EntryPKHA1_MOUSE
UniProt IDQ8BUL6
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BUL6-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q8BUL6-2; Sequence=VSP_009764, VSP_009767; Note=No experimental confirmation available.;
DomainBinds to membranes enriched in PtdIns3,4P2 via the C- terminal PH domain.
FunctionBinds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). {ECO:0000250}.
SimilarityContains 2 PH domains. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Subcellular LocationCytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Note=Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2. {ECO:0000250}.
SubunitInteracts with MPDZ and PTPN13. {ECO:0000250}.