LMPD Database


UniProt Annotations

Entry Information
Gene Nameacyl-CoA synthetase long-chain family member 4
Protein EntryACSL4_HUMAN
UniProt IDO60488
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=Long; IsoId=O60488-1; Sequence=Displayed; Name=Short; IsoId=O60488-2; Sequence=VSP_000238;
Catalytic ActivityATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
CofactorName=Mg(2+); Xref=ChEBI
DiseaseAlport syndrome with mental retardation, midface hypoplasia and elliptocytosis (ATS-MR) [MIM
DiseaseMental retardation, X-linked 63 (MRX63) [MIM
FunctionActivation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates.
SimilarityBelongs to the ATP-dependent AMP-binding enzyme family.
Subcellular LocationMitochondrion outer membrane ; Single-pass type III membrane protein . Peroxisome membrane ; Single-pass type III membrane protein {ECO