LMPD Database

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LMP002157

UniProt Annotations

Entry Information
Gene Nameacetyl-Coenzyme A acetyltransferase 1
Protein EntryTHIL_MOUSE
UniProt IDQ8QZT1
SpeciesMouse
Comments
Comment typeDescription
Catalytic Activity2 acetyl-CoA = CoA + acetoacetyl-CoA. {ECO:0000255|PROSITE-ProRule:PRU10020}.
Enzyme RegulationActivated by potassium ions, but not sodium ions. {ECO:0000250}.
FunctionPlays a major role in ketone body metabolism. {ECO:0000250}.
PtmSuccinylation at Lys-265, adjacent to a coenzyme A binding site. Desuccinylated by SIRT5. {ECO:0000269|PubMed:23806337}.
SimilarityBelongs to the thiolase family. {ECO:0000305}.
Subcellular LocationMitochondrion {ECO:0000250}.
SubunitHomotetramer. {ECO:0000250}.