LMPD Database

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LMP002154

UniProt Annotations

Entry Information
Gene Namedual adaptor for phosphotyrosine and 3-phosphoinositides 1
Protein EntryDAPP1_MOUSE
UniProt IDQ3TEK6
SpeciesMouse
Comments
Comment typeDescription
FunctionMay act as a B-cell-associated adapter that regulates B- cell antigen receptor (BCR)-signaling downstream of PI3K.
InductionUpon B-cell activation. {ECO:0000250}.
PtmPhosphorylated on tyrosine residues. {ECO:0000250}.
SimilarityContains 1 PH domain.
SimilarityContains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
SimilarityContains 1 SH2 domain. {ECO:0000255|PROSITE- ProRule:PRU00191}.
Subcellular LocationCytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Membrane-associated after cell stimulation leading to its translocation. {ECO:0000250}.
SubunitInteracts with PtdIns(3,4,5)P3 and PLCG2. {ECO:0000250}.