LMPD Database

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LMP002137

UniProt Annotations

Entry Information
Gene Namesphingosine-1-phosphate receptor 5
Protein EntryS1PR5_MOUSE
UniProt IDQ91X56
SpeciesMouse
Comments
Comment typeDescription
Developmental StageExpressed in 7-day and 17-day embryos, but not in 11-day and 15-day embryos, implying its role in mammalian development. In oligodendrocytes, expressed throughout development from the immature stages to the mature myelin-froming cell. {ECO:0000269|PubMed:15703400}.
FunctionReceptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). S1P activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival. S1P activation on O4-positive pre-oligodendrocytes induces process retraction via a Rho kinase/collapsin response-mediated protein signaling pathway. The S1P-induced survival of mature oligodendrocytes is mediated through a pertussis toxin-sensitive, Akt-dependent pathway. S1P activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival. These effects depend on the developmental stage of the cell. {ECO:0000250, ECO:0000269|PubMed:15703400}.
SimilarityBelongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular LocationCell membrane; Multi-pass membrane protein.
Tissue SpecificityExpressed in spleen and brain. In the CNS expression is restricted to oligodendrocytes. {ECO:0000269|PubMed:11705398, ECO:0000269|PubMed:15703400}.