LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP002121

UniProt Annotations

Entry Information
Gene NameCDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
Protein EntryCDIPT_MOUSE
UniProt IDQ8VDP6
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityCDP-diacylglycerol + myo-inositol = CMP + phosphatidyl-1D-myo-inositol.
CofactorName=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Divalent metal cations; Mn(2+) or Mg(2+), but Mg(2+) may be much less effective. {ECO:0000250};
FunctionCatalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme (By similarity). {ECO:0000250}.
SimilarityBelongs to the CDP-alcohol phosphatidyltransferase class-I family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Membrane {ECO:0000250}.