LMPD Database

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LMP002113

UniProt Annotations

Entry Information
Gene Namezinc finger, DHHC domain containing 7
Protein EntryZDHC7_MOUSE
UniProt IDQ91WU6
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityPalmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
DomainThe DHHC domain is required for palmitoyltransferase activity.
FunctionPalmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptors (By similarity). Palmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95. May palmitoylate GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3) and regulate their synaptic clustering and/or cell surface stability. {ECO:0000250, ECO:0000269|PubMed:15229235, ECO:0000269|PubMed:15603741}.
SimilarityBelongs to the DHHC palmitoyltransferase family. {ECO:0000305}.
SimilarityContains 1 DHHC-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00067}.
Subcellular LocationMembrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus {ECO:0000250}.
Tissue SpecificityUbiquitously expressed, with highest levels in liver, kidney and brain. Expressed in all brain regions. {ECO:0000269|PubMed:15603741}.