LMPD Database

LMP002105

Gene Information

Entrez Gene ID	239
Gene Name	arachidonate 12-lipoxygenase
Gene Symbol	ALOX12
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	IDA:UniProtKB	C	cytoplasm
GO:0005829	IDA:UniProtKB	C	cytosol
GO:0070062	IDA:UniProt	C	extracellular vesicular exosome
GO:0016020	IDA:UniProtKB	C	membrane
GO:0042383	IDA:UniProtKB	C	sarcolemma
GO:0004052	IDA:UniProtKB	F	arachidonate 12-lipoxygenase activity
GO:0051120	TAS:Reactome	F	hepoxilin A3 synthase activity
GO:0047977	ISS:UniProtKB	F	hepoxilin-epoxide hydrolase activity
GO:0005506	IEA:InterPro	F	iron ion binding
GO:0016165	IDA:UniProtKB	F	linoleate 13S-lipoxygenase activity
GO:0016702	TAS:Reactome	F	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0007568	IEA:Ensembl	P	aging
GO:0019369	IDA:UniProtKB	P	arachidonic acid metabolic process
GO:0006928	IMP:UniProtKB	P	cellular component movement
GO:0071396	IEA:Ensembl	P	cellular response to lipid
GO:0061436	ISS:UniProtKB	P	establishment of skin barrier
GO:0019395	IMP:UniProtKB	P	fatty acid oxidation
GO:0051122	ISS:UniProtKB	P	hepoxilin biosynthetic process
GO:0051121	TAS:Reactome	P	hepoxilin metabolic process
GO:1901751	IDA:UniProtKB	P	leukotriene A4 metabolic process
GO:0043651	IDA:UniProtKB	P	linoleic acid metabolic process
GO:2001303	IDA:UniProtKB	P	lipoxin A4 biosynthetic process
GO:2001306	IDA:UniProtKB	P	lipoxin B4 biosynthetic process
GO:2001300	TAS:Reactome	P	lipoxin metabolic process
GO:0019372	IDA:UniProtKB	P	lipoxygenase pathway
GO:0043066	IMP:UniProtKB	P	negative regulation of apoptotic process
GO:0010656	IMP:UniProtKB	P	negative regulation of muscle cell apoptotic process
GO:0090331	ISS:UniProtKB	P	negative regulation of platelet aggregation
GO:0045766	IMP:UniProtKB	P	positive regulation of angiogenesis
GO:0043065	IEA:Ensembl	P	positive regulation of apoptotic process
GO:0045785	IMP:UniProtKB	P	positive regulation of cell adhesion
GO:0030307	IMP:UniProtKB	P	positive regulation of cell growth
GO:0030335	IMP:UniProtKB	P	positive regulation of cell migration
GO:0008284	IMP:UniProtKB	P	positive regulation of cell proliferation
GO:0043280	IEA:Ensembl	P	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045603	IEA:Ensembl	P	positive regulation of endothelial cell differentiation
GO:0010595	IEA:Ensembl	P	positive regulation of endothelial cell migration
GO:0010628	IEA:Ensembl	P	positive regulation of gene expression
GO:0051901	IEA:Ensembl	P	positive regulation of mitochondrial depolarization
GO:0048661	IEA:Ensembl	P	positive regulation of smooth muscle cell proliferation
GO:0045909	IEA:Ensembl	P	positive regulation of vasodilation
GO:0072593	NAS:UniProtKB	P	reactive oxygen species metabolic process
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0042554	NAS:UniProtKB	P	superoxide anion generation

KEGG Pathway Links

KEGG Pathway ID	Description
hsa04750	Inflammatory mediator regulation of TRP channels
hsa04726	Serotonergic synapse

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_150320	Synthesis of Lipoxins (LX)