LMPD Database

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LMP002099

UniProt Annotations

Entry Information
Gene Namealdehyde dehydrogenase family 7, member A1
Protein EntryAL7A1_MOUSE
UniProt IDQ9DBF1
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DBF1-1; Sequence=Displayed; Name=2; IsoId=Q9DBF1-2; Sequence=VSP_038989;
Catalytic ActivityAn aldehyde + NAD(+) + H(2)O = a carboxylate + NADH.
Catalytic ActivityBetaine aldehyde + NAD(+) + H(2)O = betaine + NADH.
Catalytic Activity(S)-2-amino-6-oxohexanoate + NAD(P)(+) + H(2)O = L-2-aminoadipate + NAD(P)H.
FunctionMultifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism (By similarity). {ECO:0000250}.
PathwayAmine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1.
Sequence CautionSequence=AAH12407.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the aldehyde dehydrogenase family. {ECO:0000305}.
Subcellular LocationMitochondrion {ECO:0000269|PubMed:20207735}. Nucleus {ECO:0000269|PubMed:20207735}. Cytoplasm, cytosol {ECO:0000269|PubMed:20207735}.
SubunitHomotetramer. {ECO:0000250|UniProtKB:P83402}.
Tissue SpecificityPresent in liver, kidney, brain and pancreas, and at lower levels in jejunum, duodenum, stomach and testes (at protein level). {ECO:0000269|PubMed:20207735}.