LMPD Database

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LMP002097

UniProt Annotations

Entry Information
Gene Namehepatic nuclear factor 4, alpha
Protein EntryHNF4A_MOUSE
UniProt IDP49698
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=Long; IsoId=P49698-1; Sequence=Displayed; Name=Short; IsoId=P49698-2; Sequence=VSP_003676;
FunctionTranscriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1- antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1- alpha. May be essential for development of the liver, kidney and intestine.
MiscellaneousBinds fatty acids. {ECO:0000250}.
PtmAcetylation at Lys-458 lowers transcriptional activation by about two-fold. {ECO:0000250}.
PtmPhosphorylated on tyrosine residue(s); phosphorylation is important for its DNA-binding activity. Phosphorylation may directly or indirectly play a regulatory role in the subnuclear distribution. Phosphorylation at Ser-313 by AMPK reduces the ability to form homodimers and bind DNA (By similarity). {ECO:0000250}.
Sequence CautionSequence=BAA06101.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the nuclear hormone receptor family. NR2 subfamily. {ECO:0000305}.
SimilarityContains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular LocationNucleus.
SubunitHomodimerization is required for HNF4-alpha to bind to its recognition site. Interacts with PER2. {ECO:0000269|PubMed:20159955}.