LMPD Database

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LMP002086

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 11, subfamily B, polypeptide 1
Protein EntryC11B1_HUMAN
UniProt IDP15538
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P15538-1; Sequence=Displayed; Name=2; IsoId=P15538-2; Sequence=VSP_043308; Note=No experimental confirmation available.;
Catalytic ActivityA steroid + 2 reduced adrenodoxin + O(2) + 2 H(+) = an 11-beta- hydroxysteroid + 2 oxidized adrenodoxin + H(2)O.
CofactorName=heme; Xref=ChEBI
DiseaseAdrenal hyperplasia 4 (AH4) [MIM
DiseaseFamilial hyperaldosteronism 1 (FH1) [MIM
FunctionHas steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.
SimilarityBelongs to the cytochrome P450 family.
Subcellular LocationMitochondrion membrane.