LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP002055

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 21, subfamily a, polypeptide 1
Protein EntryCP21A_MOUSE
UniProt IDP03940
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityA C(21) steroid + (reduced NADPH--hemoprotein reductase) + O(2) = a 21-hydroxy-C(21)-steroid + (oxidized NADPH-- hemoprotein reductase) + H(2)O.
CofactorName=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
DomainThe leucine-rich hydrophobic amino acid N-terminal region probably helps to anchor the protein to the microsomal membrane.
FunctionSpecifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids.
SimilarityBelongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.