LMPD Database

LMP002054

Gene Information

Entrez Gene ID	5590
Gene Name	protein kinase C, zeta
Gene Symbol	PRKCZ
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0045179	IEA:Ensembl	C	apical cortex
GO:0016324	IEA:Ensembl	C	apical plasma membrane
GO:0043203	IEA:Ensembl	C	axon hillock
GO:0005911	IDA:UniProtKB	C	cell-cell junction
GO:0030054	TAS:Reactome	C	cell junction
GO:0031252	IEA:Ensembl	C	cell leading edge
GO:0005737	TAS:ProtInc	C	cytoplasm
GO:0005829	IEA:Ensembl	C	cytosol
GO:0005768	IEA:UniProtKB-KW	C	endosome
GO:0070062	IDA:UniProt	C	extracellular vesicular exosome
GO:0016020	TAS:ProtInc	C	membrane
GO:0045121	IEA:Ensembl	C	membrane raft
GO:0005815	IEA:Ensembl	C	microtubule organizing center
GO:0035748	IEA:Ensembl	C	myelin sheath abaxonal region
GO:0005635	IEA:Ensembl	C	nuclear envelope
GO:0016363	IEA:Ensembl	C	nuclear matrix
GO:0048471	IEA:Ensembl	C	perinuclear region of cytoplasm
GO:0005886	TAS:ProtInc	C	plasma membrane
GO:0043234	IEA:Ensembl	C	protein complex
GO:0005923	IEA:Ensembl	C	tight junction
GO:0005524	IEA:UniProtKB-KW	F	ATP binding
GO:0043560	IC:BHF-UCL	F	insulin receptor substrate binding
GO:0015459	IEA:Ensembl	F	potassium channel regulator activity
GO:0004672	IDA:UniProtKB	F	protein kinase activity
GO:0004697	IEA:UniProtKB-EC	F	protein kinase C activity
GO:0004674	IDA:BHF-UCL	F	protein serine/threonine kinase activity
GO:0008270	IEA:InterPro	F	zinc ion binding
GO:0031532	IEA:Ensembl	P	actin cytoskeleton reorganization
GO:0031584	IEA:Ensembl	P	activation of phospholipase D activity
GO:0032148	IEA:Ensembl	P	activation of protein kinase B activity
GO:0007596	TAS:Reactome	P	blood coagulation
GO:0016477	IEA:Ensembl	P	cell migration
GO:0030010	ISS:UniProtKB	P	establishment of cell polarity
GO:0006954	IEA:UniProtKB-KW	P	inflammatory response
GO:0008286	IEA:Ensembl	P	insulin receptor signaling pathway
GO:0007616	IEA:Ensembl	P	long-term memory
GO:0060291	ISS:UniProtKB	P	long-term synaptic potentiation
GO:0060081	IEA:Ensembl	P	membrane hyperpolarization
GO:0000226	IEA:Ensembl	P	microtubule cytoskeleton organization
GO:0043066	TAS:ProtInc	P	negative regulation of apoptotic process
GO:0051346	IEA:Ensembl	P	negative regulation of hydrolase activity
GO:0046627	IMP:BHF-UCL	P	negative regulation of insulin receptor signaling pathway
GO:0050732	IMP:BHF-UCL	P	negative regulation of peptidyl-tyrosine phosphorylation
GO:0031333	IMP:BHF-UCL	P	negative regulation of protein complex assembly
GO:1990138	IEA:Ensembl	P	neuron projection extension
GO:0018105	IDA:BHF-UCL	P	peptidyl-serine phosphorylation
GO:0030168	TAS:Reactome	P	platelet activation
GO:0001954	IEA:Ensembl	P	positive regulation of cell-matrix adhesion
GO:0008284	IEA:Ensembl	P	positive regulation of cell proliferation
GO:0070374	IMP:UniProtKB	P	positive regulation of ERK1 and ERK2 cascade
GO:2000463	ISS:UniProtKB	P	positive regulation of excitatory postsynaptic membrane potential
GO:0046326	IEA:Ensembl	P	positive regulation of glucose import
GO:0046628	ISS:UniProtKB	P	positive regulation of insulin receptor signaling pathway
GO:2001181	ISS:UniProtKB	P	positive regulation of interleukin-10 secretion
GO:2000667	ISS:UniProtKB	P	positive regulation of interleukin-13 secretion
GO:0032753	ISS:UniProtKB	P	positive regulation of interleukin-4 production
GO:2000664	ISS:UniProtKB	P	positive regulation of interleukin-5 secretion
GO:0051092	ISS:UniProtKB	P	positive regulation of NF-kappaB transcription factor activity
GO:2000553	ISS:UniProtKB	P	positive regulation of T-helper 2 cell cytokine production
GO:0045630	ISS:UniProtKB	P	positive regulation of T-helper 2 cell differentiation
GO:0051291	IEA:Ensembl	P	protein heterooligomerization
GO:0070528	IEA:Ensembl	P	protein kinase C signaling
GO:0072659	IEA:Ensembl	P	protein localization to plasma membrane
GO:0006468	IDA:UniProtKB	P	protein phosphorylation
GO:0007165	TAS:ProtInc	P	signal transduction
GO:0007179	TAS:Reactome	P	transforming growth factor beta receptor signaling pathway
GO:0047496	IEA:Ensembl	P	vesicle transport along microtubule

KEGG Pathway Links

KEGG Pathway ID	Description
hsa04390	Hippo signaling pathway
hsa04611	Platelet activation
hsa04015	Rap1 signaling pathway