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LMP002040

UniProt Annotations

Entry Information
Gene Namemacrophage scavenger receptor 1
Protein EntryMSRE_HUMAN
UniProt IDP21757
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=I; IsoId=P21757-1; Sequence=Displayed; Name=II; IsoId=P21757-2; Sequence=VSP_006229, VSP_006230; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=III; IsoId=P21757-3; Sequence=VSP_036842;
DiseaseBarrett esophagus (BE) [MIM
DiseaseProstate cancer (PC) [MIM
FunctionMembrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize acetylated LDL.
InteractionQ86VS8:HOOK3; NbExp=4; IntAct=EBI-1776976, EBI-1777078; Q7TQ77:Hook3 (xeno); NbExp=2; IntAct=EBI-1776976, EBI-1777000;
SimilarityContains 1 collagen-like domain.
SimilarityContains 1 SRCR domain. {ECO
Subcellular LocationMembrane; Single-pass type II membrane protein.
SubunitHomotrimer.
Tissue SpecificityIsoform I, isoform II and isoform III are expressed in monocyte-derived macrophages.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/msr1/";