LMPD Database

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LMP002038

UniProt Annotations

Entry Information
Gene Namearylsulfatase A
Protein EntryARSA_MOUSE
UniProt IDP50428
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityA cerebroside 3-sulfate + H(2)O = a cerebroside + sulfate.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000250};
FunctionHydrolyzes cerebroside sulfate.
PtmThe conversion to 3-oxoalanine (also known as C- formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. {ECO:0000250}.
SimilarityBelongs to the sulfatase family. {ECO:0000305}.
Subcellular LocationLysosome.
SubunitHomodimer at neutral pH and homooctamer at acidic pH. Exists both as a single chain of 58 kDa (component A) or as a chain of 50 kDa (component B) linked by disulfide bond(s) to a 7 kDa chain (component C). Interacts with SUMF1 (By similarity). {ECO:0000250}.