LMPD Database

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LMP002037

UniProt Annotations

Entry Information
Gene Namesteroid sulfatase
Protein EntrySTS_MOUSE
UniProt IDP50427
SpeciesMouse
Comments
Comment typeDescription
Catalytic Activity3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H(2)O = 3-beta-hydroxyandrost-5-en-17-one + sulfate.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000250};
FunctionConversion of sulfated steroid precursors to estrogens during pregnancy.
PtmThe conversion to 3-oxoalanine (also known as C- formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. {ECO:0000250}.
SimilarityBelongs to the sulfatase family. {ECO:0000305}.
Subcellular LocationMicrosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=The sequence shows several membrane-spanning domains that could serve to anchor the protein in the microsomal membrane.
SubunitHomodimer.