LMPD Database

LMP002036

Gene Information

Entrez Gene ID	11816
Gene Name	apolipoprotein E
Gene Symbol	Apoe
Species	Mus musculus

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0072562	IEA:Ensembl	C	blood microparticle
GO:0042627	IEA:UniProtKB-KW	C	chylomicron
GO:0005829	TAS:Reactome	C	cytosol
GO:0030425	IEA:Ensembl	C	dendrite
GO:0005576	TAS:Reactome	C	extracellular region
GO:0005615	IDA:MGI	C	extracellular space
GO:0070062	IEA:Ensembl	C	extracellular vesicular exosome
GO:0031232	IEA:Ensembl	C	extrinsic component of external side of plasma membrane
GO:0005794	IEA:Ensembl	C	Golgi apparatus
GO:0034364	IEA:UniProtKB-KW	C	high-density lipoprotein particle
GO:0034363	IEA:Ensembl	C	intermediate-density lipoprotein particle
GO:0005770	IEA:Ensembl	C	late endosome
GO:0034362	IDA:BHF-UCL	C	low-density lipoprotein particle
GO:0043025	IEA:Ensembl	C	neuronal cell body
GO:0005634	IEA:Ensembl	C	nucleus
GO:0034361	IEA:UniProtKB-KW	C	very-low-density lipoprotein particle
GO:0016209	IEA:Ensembl	F	antioxidant activity
GO:0001540	ISS:UniProtKB	F	beta-amyloid binding
GO:0017127	IDA:MGI	F	cholesterol transporter activity
GO:0008201	IEA:UniProtKB-KW	F	heparin binding
GO:0046848	IEA:Ensembl	F	hydroxyapatite binding
GO:0071813	IDA:MGI	F	lipoprotein particle binding
GO:0046911	IEA:Ensembl	F	metal chelating activity
GO:0060228	IMP:BHF-UCL	F	phosphatidylcholine-sterol O-acyltransferase activator activity
GO:0005543	IEA:Ensembl	F	phospholipid binding
GO:0007568	IEA:Ensembl	P	aging
GO:0048844	IGI:MGI	P	artery morphogenesis
GO:0072358	IMP:MGI	P	cardiovascular system development
GO:0006874	IDA:MGI	P	cellular calcium ion homeostasis
GO:0071397	IEA:Ensembl	P	cellular response to cholesterol
GO:0071363	IEA:Ensembl	P	cellular response to growth factor stimulus
GO:0071347	IEA:Ensembl	P	cellular response to interleukin-1
GO:0019934	IEA:Ensembl	P	cGMP-mediated signaling
GO:0006707	IMP:MGI	P	cholesterol catabolic process
GO:0033344	IDA:MGI	P	cholesterol efflux
GO:0042632	IMP:MGI	P	cholesterol homeostasis
GO:0008203	IMP:MGI	P	cholesterol metabolic process
GO:0034382	IEA:Ensembl	P	chylomicron remnant clearance
GO:0055089	IEA:Ensembl	P	fatty acid homeostasis
GO:0007186	IEA:Ensembl	P	G-protein coupled receptor signaling pathway
GO:0034380	IEA:Ensembl	P	high-density lipoprotein particle assembly
GO:0034384	IEA:Ensembl	P	high-density lipoprotein particle clearance
GO:0034375	IEA:Ensembl	P	high-density lipoprotein particle remodeling
GO:0055088	IMP:MGI	P	lipid homeostasis
GO:0006629	IGI:MGI	P	lipid metabolic process
GO:0042158	IGI:MGI	P	lipoprotein biosynthetic process
GO:0042159	IMP:MGI	P	lipoprotein catabolic process
GO:0042157	IMP:MGI	P	lipoprotein metabolic process
GO:0015909	IEA:Ensembl	P	long-chain fatty acid transport
GO:0034374	IMP:BHF-UCL	P	low-density lipoprotein particle remodeling
GO:0051651	IMP:MGI	P	maintenance of location in cell
GO:1902430	IEA:Ensembl	P	negative regulation of beta-amyloid formation
GO:0043537	IEA:Ensembl	P	negative regulation of blood vessel endothelial cell migration
GO:0045541	IEA:Ensembl	P	negative regulation of cholesterol biosynthetic process
GO:0090370	IEA:Ensembl	P	negative regulation of cholesterol efflux
GO:0061000	IEA:Ensembl	P	negative regulation of dendritic spine development
GO:1902951	IEA:Ensembl	P	negative regulation of dendritic spine maintenance
GO:0001937	IEA:Ensembl	P	negative regulation of endothelial cell proliferation
GO:0050728	IGI:UniProtKB	P	negative regulation of inflammatory response
GO:1903001	IEA:Ensembl	P	negative regulation of lipid transport across blood brain barrier
GO:0043407	IEA:Ensembl	P	negative regulation of MAP kinase activity
GO:0043524	IEA:Ensembl	P	negative regulation of neuron apoptotic process
GO:1902999	IEA:Ensembl	P	negative regulation of phospholipid efflux
GO:0010544	IEA:Ensembl	P	negative regulation of platelet activation
GO:1901627	IEA:Ensembl	P	negative regulation of postsynaptic membrane organization
GO:1901630	IEA:Ensembl	P	negative regulation of presynaptic membrane organization
GO:0007263	IEA:Ensembl	P	nitric oxide mediated signal transduction
GO:0048709	IEA:Ensembl	P	oligodendrocyte differentiation
GO:0033700	IEA:Ensembl	P	phospholipid efflux
GO:0045773	IEA:Ensembl	P	positive regulation of axon extension
GO:1902004	IEA:Ensembl	P	positive regulation of beta-amyloid formation
GO:0030828	IEA:Ensembl	P	positive regulation of cGMP biosynthetic process
GO:0010875	IEA:Ensembl	P	positive regulation of cholesterol efflux
GO:0010873	IMP:BHF-UCL	P	positive regulation of cholesterol esterification
GO:0060999	IEA:Ensembl	P	positive regulation of dendritic spine development
GO:1902952	IEA:Ensembl	P	positive regulation of dendritic spine maintenance
GO:0046889	IEA:Ensembl	P	positive regulation of lipid biosynthetic process
GO:1903002	IEA:Ensembl	P	positive regulation of lipid transport across blood brain barrier
GO:0032805	IEA:Ensembl	P	positive regulation of low-density lipoprotein particle receptor catabolic process
GO:0051044	IEA:Ensembl	P	positive regulation of membrane protein ectodomain proteolysis
GO:1902998	IEA:Ensembl	P	positive regulation of neurofibrillary tangle assembly
GO:1901216	IEA:Ensembl	P	positive regulation of neuron death
GO:0051000	IEA:Ensembl	P	positive regulation of nitric-oxide synthase activity
GO:1902995	IEA:Ensembl	P	positive regulation of phospholipid efflux
GO:1901628	IEA:Ensembl	P	positive regulation of postsynaptic membrane organization
GO:1901631	IEA:Ensembl	P	positive regulation of presynaptic membrane organization
GO:0006898	IEA:Ensembl	P	receptor-mediated endocytosis
GO:1900221	IEA:Ensembl	P	regulation of beta-amyloid clearance
GO:0032489	IEA:Ensembl	P	regulation of Cdc42 protein signal transduction
GO:0010468	IMP:MGI	P	regulation of gene expression
GO:1902947	IEA:Ensembl	P	regulation of tau-protein kinase activity
GO:0002021	IMP:MGI	P	response to dietary excess
GO:0045471	IEA:Ensembl	P	response to ethanol
GO:0032868	IEA:Ensembl	P	response to insulin
GO:0006979	IMP:MGI	P	response to oxidative stress
GO:0032526	IEA:Ensembl	P	response to retinoic acid
GO:0043691	IEA:Ensembl	P	reverse cholesterol transport
GO:0006641	IEA:Ensembl	P	triglyceride metabolic process
GO:0042311	IMP:MGI	P	vasodilation
GO:0034447	IEA:Ensembl	P	very-low-density lipoprotein particle clearance
GO:0034372	IMP:BHF-UCL	P	very-low-density lipoprotein particle remodeling

KEGG Pathway Links

KEGG Pathway ID	Description
mmu05010	Alzheimer's disease

REACTOME Pathway Links

REACTOME Pathway ID	Description
5893389	Chylomicron-mediated lipid transport
5893599	HDL-mediated lipid transport