LMPD Database

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LMP002015

UniProt Annotations

Entry Information
Gene NameATPase, aminophospholipid transporter, class I, type 8B, member 3
Protein EntryAT8B3_HUMAN
UniProt IDO60423
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=O60423-2; Sequence=Displayed; Name=2; IsoId=O60423-1; Sequence=VSP_039716; Note=No experimental confirmation available.; Name=3; IsoId=O60423-3; Sequence=VSP_043554, VSP_043555, VSP_039716; Note=No experimental confirmation available.;
Catalytic ActivityATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).
FunctionP4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May be responsible for the maintenance of asymmetric distribution of phosphatidylserine (PS) in spermatozoa membranes. Involved in acrosome reactions and binding of spermatozoa to zona pellucida (By similarity).
MiscellaneousAssociation with flippase complex beta subunits TMEM30A and TMEM30A has not been detected, neither did their coexpression change the localization in ER.
Sequence CautionSequence=AAC17601.1; Type=Erroneous gene model prediction; Evidence= ; Sequence=BAB71492.1; Type=Erroneous initiation; Evidence= ;
SimilarityBelongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
Subcellular LocationCytoplasmic vesicle, secretory vesicle, acrosome membrane ; Multi-pass membrane protein . Endoplasmic reticulum .
Tissue SpecificityIsoform 3 was only detected in testis.