LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP001998

UniProt Annotations

Entry Information
Gene Namesurfactant associated protein B
Protein EntryS4R2L6_MOUSE
UniProt IDS4R2L6
SpeciesMouse
Comments
Comment typeDescription
FunctionPulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.
MiscellaneousPulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).
SimilarityContains 1 saposin A-type domain. {ECO:0000255|PROSITE-ProRule:PRU00414}.
SimilarityContains 3 saposin B-type domains. {ECO:0000255|PROSITE-ProRule:PRU00415}.
Subcellular LocationSecreted, extracellular space, surface film.
SubunitHomodimer; disulfide-linked.