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LMP001983

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 3, subfamily A, polypeptide 43
Protein EntryCP343_HUMAN
UniProt IDQ9HB55
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q9HB55-1; Sequence=Displayed; Name=2; IsoId=Q9HB55-2; Sequence=VSP_000609; Name=3; IsoId=Q9HB55-3; Sequence=VSP_000610, VSP_000611; Name=4; IsoId=Q9HB55-4; Sequence=VSP_000612, VSP_000613; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=7; IsoId=Q9HB55-6; Sequence=VSP_056736;
Catalytic ActivityRH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.
CofactorName=heme; Xref=ChEBI
FunctionExhibits low testosterone 6-beta-hydroxylase activity.
InductionBy rifampicin.
MiscellaneousChimeric transcripts, characterized by CYP3A43 exon 1 joined at canonical splice sites to distinct sets of CYP3A4 or CYP3A5 exons, have been detected. All are possibly produced by trans-splicing. CYP3A43-CYP3A4 chimeric transcripts exist in 3 different combinations: CYP3A43 exon 1 joined in frame to CYP3A4 exons 2-13, CYP3A43 exon 1 joined in frame to CYP3A4 exons 4-13 and CYP3A43 exon 1 joined in frame to CYP3A4 exon 7-13. The longest chimeric isoform (CYP3A43 exon 1 joined to CYP3A4 exons 2- 13) exhibits 6-beta-hydroxylase activity, while a shorter isoform (CYP3A43 exon 1 joined to CYP3A4 exons 4-13) does not. CYP3A43- CYP3A5 chimeric transcripts exist in 2 different combinations: CYP3A43 exon 1 joined in frame to CYP3A5 exon 11-13 and CYP3A43 exon 1 joined in frame to CYP3A5 exon 12-13. All chimeric transcripts are expressed at very low levels in the liver (PubMed:11726664).
PolymorphismAt protein level, three alleles are known: CYP3A43*1, CYP3A43*2 and CYP3A43*3. The sequence shown is that of CYP3A43*1, which is the most frequent allele. The allele CYP3A43*2 is likely to be non-functional.
SimilarityBelongs to the cytochrome P450 family.
Subcellular LocationEndoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue SpecificityHighest expression level in prostate. Also expressed in liver, kidney, pancreas, fetal liver and fetal skeletal muscle. {ECO
Web ResourceName=Cytochrome P450 Allele Nomenclature Committee; Note=CYP3A43 alleles; URL="http://www.cypalleles.ki.se/cyp3a43.htm";