LMPD Database

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LMP001948

UniProt Annotations

Entry Information
Gene Nameprostaglandin E receptor 4 (subtype EP4)
Protein EntryQ91VE4_MOUSE
UniProt IDQ91VE4
SpeciesMouse
Comments
Comment typeDescription
CautionWas originally designated as the EP2 subtype. {ECO:0000305}.
FunctionReceptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.
PtmPhosphorylation mediates agonist-mediated desensitization by promoting cytoplasmic retention. {ECO:0000250}.
SimilarityBelongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular LocationCell membrane; Multi-pass membrane protein.
SubunitInteracts with FEM1A. {ECO:0000250}.
Tissue SpecificityAbundant expression in ileum, thymus and mastocytoma P-815 cells. Also observed in lung, spleen, heart and uterus.