LMPD Database

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LMP001910

UniProt Annotations

Entry Information
Gene NameRNA binding motif protein 14
Protein EntryRBM14_HUMAN
UniProt IDQ96PK6
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; Synonyms=CoAA; IsoId=Q96PK6-1; Sequence=Displayed; Name=2; Synonyms=CoAM; IsoId=Q96PK6-2; Sequence=VSP_015078, VSP_015079; Name=3; IsoId=Q96PK6-3; Sequence=VSP_044641, VSP_044642; Note=No experimental confirmation available.; Name=4; IsoId=Q96PK6-4; Sequence=VSP_047109, VSP_047110; Name=5; IsoId=Q96PK6-5; Sequence=VSP_047494, VSP_047495;
FunctionIsoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1.
SimilarityContains 2 RRM (RNA recognition motif) domains.
Subcellular LocationNucleus. Nucleus, nucleolus. Note=In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles.
SubunitIsoform 1 interacts with NCOA6, CITED1 and XRCC5/KU86. Isoform 1 interacts with SS18 isoform 1. Isoform 1 interacts with SS18 isoform 2. {ECO
Tissue SpecificityExpressed in all tissues tested, including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood lymphocytes.