LMPD Database

LMP001896

Record overview

LMPD ID	LMP001896
Gene ID	6462
Species	Homo sapiens (Human)
Gene Name	sex hormone-binding globulin
Gene Symbol	SHBG
Synonyms	ABP; SBP; TEBG
Chromosome	17
Map Location	17p13.1
Summary	This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers. Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Orthologs	View orthologs and multiple alignments for SHBG

Proteins

sex hormone-binding globulin isoform 1 precursor

Refseq ID:	NP_001031
Protein GI:	7382460
UniProt ID:	P04278
mRNA ID:	NM_001040
Length:	402
RefSeq Status:	REVIEWED

MESRGPLATSRLLLLLLLLLLRHTRQGWALRPVLPTQSAHDPPAVHLSNGPGQEPIAVMTFDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGL
RDGRPEIQLHNHWAQLTVGAGPRLDDGRWHQVEVKMEGDSVLLEVDGEEVLRLRQVSGPLTSKRHPIMRIALGGLLFPASNLRLPLVPALDGCLRRDSWL
DKQAEISASAPTSLRSCDVESNPGIFLPPGTQAEFNLRDIPQPHAEPWAFSLDLGLKQAAGSGHLLALGTPENPSWLSLHLQDQKVVLSSGSGPGLDLPL
VLGLPLQLKLSMSRVVLSQGSKMKALALPPLGLAPLLNLWAKPQGRLFLGALPGEDSSTSFCLNGLWAQGQRLDVDQALNRSHEIWTHSCPQSPGNGTDA
SH

sex hormone-binding globulin isoform 2 precursor

Refseq ID:	NP_001139751
Protein GI:	7382460
UniProt ID:	P04278
mRNA ID:	NM_001146279
Length:	402
RefSeq Status:	REVIEWED

MESRGPLATSRLLLLLLLLLLRHTRQGWALRPVLPTQSAHDPPAVHLSNGPGQEPIAVMTFDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGL
RDGRPEIQLHNHWAQLTVGAGPRLDDGRWHQVEVKMEGDSVLLEVDGEEVLRLRQVSGPLTSKRHPIMRIALGGLLFPASNLRLPLVPALDGCLRRDSWL
DKQAEISASAPTSLRSCDVESNPGIFLPPGTQAEFNLRDIPQPHAEPWAFSLDLGLKQAAGSGHLLALGTPENPSWLSLHLQDQKVVLSSGSGPGLDLPL
VLGLPLQLKLSMSRVVLSQGSKMKALALPPLGLAPLLNLWAKPQGRLFLGALPGEDSSTSFCLNGLWAQGQRLDVDQALNRSHEIWTHSCPQSPGNGTDA
SH

sex hormone-binding globulin isoform 3 precursor

Refseq ID:	NP_001139752
Protein GI:	7382460
UniProt ID:	P04278
mRNA ID:	NM_001146280
Length:	402
RefSeq Status:	REVIEWED

MESRGPLATSRLLLLLLLLLLRHTRQGWALRPVLPTQSAHDPPAVHLSNGPGQEPIAVMTFDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGL
RDGRPEIQLHNHWAQLTVGAGPRLDDGRWHQVEVKMEGDSVLLEVDGEEVLRLRQVSGPLTSKRHPIMRIALGGLLFPASNLRLPLVPALDGCLRRDSWL
DKQAEISASAPTSLRSCDVESNPGIFLPPGTQAEFNLRDIPQPHAEPWAFSLDLGLKQAAGSGHLLALGTPENPSWLSLHLQDQKVVLSSGSGPGLDLPL
VLGLPLQLKLSMSRVVLSQGSKMKALALPPLGLAPLLNLWAKPQGRLFLGALPGEDSSTSFCLNGLWAQGQRLDVDQALNRSHEIWTHSCPQSPGNGTDA
SH

sex hormone-binding globulin isoform 4 precursor

Refseq ID:	NP_001139753
Protein GI:	7382460
UniProt ID:	P04278
mRNA ID:	NM_001146281
Length:	402
RefSeq Status:	REVIEWED

MESRGPLATSRLLLLLLLLLLRHTRQGWALRPVLPTQSAHDPPAVHLSNGPGQEPIAVMTFDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGL
RDGRPEIQLHNHWAQLTVGAGPRLDDGRWHQVEVKMEGDSVLLEVDGEEVLRLRQVSGPLTSKRHPIMRIALGGLLFPASNLRLPLVPALDGCLRRDSWL
DKQAEISASAPTSLRSCDVESNPGIFLPPGTQAEFNLRDIPQPHAEPWAFSLDLGLKQAAGSGHLLALGTPENPSWLSLHLQDQKVVLSSGSGPGLDLPL
VLGLPLQLKLSMSRVVLSQGSKMKALALPPLGLAPLLNLWAKPQGRLFLGALPGEDSSTSFCLNGLWAQGQRLDVDQALNRSHEIWTHSCPQSPGNGTDA
SH

sex hormone-binding globulin isoform 5

Refseq ID:	NP_001276042
Protein GI:	574287849
UniProt ID:	P04278
mRNA ID:	NM_001289113
Length:	344
RefSeq Status:	REVIEWED

sex hormone-binding globulin isoform 5
`MTFDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGLRDGRPEIQLHNHWAQLTVGAGPRLDDGRWHQVEVKMEGDSVLLEVDGEEVLRLRQVSG PLTSKRHPIMRIALGGLLFPASNLRLPLVPALDGCLRRDSWLDKQAEISASAPTSLRSCDVESNPGIFLPPGTQAEFNLRDIPQPHAEPWAFSLDLGLKQ AAGSGHLLALGTPENPSWLSLHLQDQKVVLSSGSGPGLDLPLVLGLPLQLKLSMSRVVLSQGSKMKALALPPLGLAPLLNLWAKPQGRLFLGALPGEDSS TSFCLNGLWAQGQRLDVDQALNRSHEIWTHSCPQSPGNGTDASH`

Refseq ID:	NP_001276043
Protein GI:	574287947
UniProt ID:	P04278
mRNA ID:	NM_001289114
Length:	344
RefSeq Status:	REVIEWED

sex hormone-binding globulin isoform 6
Protein sequence is identical to GI:574287849 (mRNA isoform)

Refseq ID:	NP_001276044
Protein GI:	574288150
UniProt ID:	P04278
mRNA ID:	NM_001289115
Length:	235
RefSeq Status:	REVIEWED

sex hormone-binding globulin isoform 7
`MTFDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGLRDGRPEIQLHNHWAQLTVGAGPRLDDGRWHQVEVKMEGDSVLLEVDGEEVLRLRQVSG PLTSKRHPIMRIALGGLLFPASNLRLPLVPALDGCLRRDSWLDKQAEISASAPTSLRSCDVESNPGIFLPPGTQAEFNLRDIPQPHAEPWAFSLDLGLKQ AAGSGHLLALGTPENPSWLSLHLQDQEKTLPPLFA`

Refseq ID:	NP_001276045
Protein GI:	574288150
UniProt ID:	P04278
mRNA ID:	NM_001289116
Length:	235
RefSeq Status:	REVIEWED

`MTFDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGLRDGRPEIQLHNHWAQLTVGAGPRLDDGRWHQVEVKMEGDSVLLEVDGEEVLRLRQVSG PLTSKRHPIMRIALGGLLFPASNLRLPLVPALDGCLRRDSWLDKQAEISASAPTSLRSCDVESNPGIFLPPGTQAEFNLRDIPQPHAEPWAFSLDLGLKQ AAGSGHLLALGTPENPSWLSLHLQDQEKTLPPLFA`

sig_peptide: 1..29
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3329
peptide sequence: 
MESRGPLATSRLLLLLLLLLLRHTRQGWA

mat_peptide: 30..402
product: Sex hormone-binding globulin
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P04278.2)
calculated_mol_wt: 40468
peptide sequence: 
LRPVLPTQSAHDPPAVHLSNGPGQEPIAVMTFDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGLRDGRPEIQLHNHWAQLTVGAGPRLDDGRW
HQVEVKMEGDSVLLEVDGEEVLRLRQVSGPLTSKRHPIMRIALGGLLFPASNLRLPLVPALDGCLRRDSWLDKQAEISASAPTSLRSCDVESNPGIFLPP
GTQAEFNLRDIPQPHAEPWAFSLDLGLKQAAGSGHLLALGTPENPSWLSLHLQDQKVVLSSGSGPGLDLPLVLGLPLQLKLSMSRVVLSQGSKMKALALP
PLGLAPLLNLWAKPQGRLFLGALPGEDSSTSFCLNGLWAQGQRLDVDQALNRSHEIWTHSCPQSPGNGTDASH

sig_peptide: 1..29
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3329
peptide sequence: 
MESRGPLATSRLLLLLLLLLLRHTRQGWA

sig_peptide: 1..29
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3329
peptide sequence: 
MESRGPLATSRLLLLLLLLLLRHTRQGWA

sig_peptide: 1..29
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3329
peptide sequence: 
MESRGPLATSRLLLLLLLLLLRHTRQGWA