LMPD Database

LMP001886

Gene Information

Entrez Gene ID	5562
Gene Name	protein kinase, AMP-activated, alpha 1 catalytic subunit
Gene Symbol	PRKAA1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0031588	ISS:UniProtKB	C	AMP-activated protein kinase complex
GO:0016324	IEA:Ensembl	C	apical plasma membrane
GO:0005737	IDA:HPA	C	cytoplasm
GO:0005829	TAS:Reactome	C	cytosol
GO:0005622	IC:UniProtKB	C	intracellular
GO:0005634	ISS:UniProtKB	C	nucleus
GO:0050405	IEA:UniProtKB-EC	F	[acetyl-CoA carboxylase] kinase activity
GO:0004679	IDA:UniProtKB	F	AMP-activated protein kinase activity
GO:0005524	IEA:UniProtKB-KW	F	ATP binding
GO:0004691	NAS:UniProtKB	F	cAMP-dependent protein kinase activity
GO:0003682	ISS:UniProtKB	F	chromatin binding
GO:0035174	ISS:UniProtKB	F	histone serine kinase activity
GO:0047322	IEA:UniProtKB-EC	F	[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
GO:0046872	IEA:UniProtKB-KW	F	metal ion binding
GO:0004672	IDA:UniProtKB	F	protein kinase activity
GO:0050321	IEA:UniProtKB-EC	F	tau-protein kinase activity
GO:0000187	NAS:UniProtKB	P	activation of MAPK activity
GO:0006914	IEA:UniProtKB-KW	P	autophagy
GO:0007050	TAS:Reactome	P	cell cycle arrest
GO:0071361	IEA:Ensembl	P	cellular response to ethanol
GO:0042149	ISS:UniProtKB	P	cellular response to glucose starvation
GO:0070301	IEA:Ensembl	P	cellular response to hydrogen peroxide
GO:0071456	IEA:Ensembl	P	cellular response to hypoxia
GO:0031669	ISS:UniProtKB	P	cellular response to nutrient levels
GO:0006695	IEA:UniProtKB-KW	P	cholesterol biosynthetic process
GO:0009631	IEA:Ensembl	P	cold acclimation
GO:0006633	IEA:UniProtKB-KW	P	fatty acid biosynthetic process
GO:0055089	ISS:UniProtKB	P	fatty acid homeostasis
GO:0019395	IEA:Ensembl	P	fatty acid oxidation
GO:0042593	ISS:UniProtKB	P	glucose homeostasis
GO:0006006	IEA:Ensembl	P	glucose metabolic process
GO:0008286	TAS:Reactome	P	insulin receptor signaling pathway
GO:0008610	ISS:UniProtKB	P	lipid biosynthetic process
GO:0043066	ISS:UniProtKB	P	negative regulation of apoptotic process
GO:2001274	IEA:Ensembl	P	negative regulation of glucose import in response to insulin stimulus
GO:0046318	NAS:UniProtKB	P	negative regulation of glucosylceramide biosynthetic process
GO:0050995	ISS:UniProtKB	P	negative regulation of lipid catabolic process
GO:0032007	ISS:UniProtKB	P	negative regulation of TOR signaling
GO:0010508	ISS:UniProtKB	P	positive regulation of autophagy
GO:0008284	IEA:Ensembl	P	positive regulation of cell proliferation
GO:0045542	NAS:UniProtKB	P	positive regulation of cholesterol biosynthetic process
GO:0010628	IDA:UniProtKB	P	positive regulation of gene expression
GO:0045821	ISS:UniProtKB	P	positive regulation of glycolytic process
GO:0051291	IEA:Ensembl	P	protein heterooligomerization
GO:0006468	IDA:UniProtKB	P	protein phosphorylation
GO:0042752	ISS:UniProtKB	P	regulation of circadian rhythm
GO:2000505	ISS:UniProtKB	P	regulation of energy homeostasis
GO:0006355	IEA:UniProtKB-KW	P	regulation of transcription, DNA-templated
GO:0060627	IEA:Ensembl	P	regulation of vesicle-mediated transport
GO:0014823	IEA:Ensembl	P	response to activity
GO:0031000	IEA:Ensembl	P	response to caffeine
GO:1901563	IEA:Ensembl	P	response to camptothecin
GO:0010332	ISS:UniProtKB	P	response to gamma radiation
GO:0001666	NAS:UniProtKB	P	response to hypoxia
GO:0009411	IEA:Ensembl	P	response to UV
GO:0048511	IEA:UniProtKB-KW	P	rhythmic process
GO:0007165	TAS:ProtInc	P	signal transduction
GO:0006351	IEA:UniProtKB-KW	P	transcription, DNA-templated
GO:0016055	IEA:UniProtKB-KW	P	Wnt signaling pathway

KEGG Pathway Links

KEGG Pathway ID	Description
hsa04152	AMPK signaling pathway
hsa04068	FoxO signaling pathway
hsa04932	Non-alcoholic fatty liver disease (NAFLD)
hsa04921	Oxytocin signaling pathway