LMPD Database

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LMP001859

UniProt Annotations

Entry Information
Gene Namephospholipase A2, group IVE
Protein EntryPA24E_MOUSE
UniProt IDQ50L42
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q50L42-1; Sequence=Displayed; Name=2; IsoId=Q50L42-2; Sequence=VSP_019884, VSP_019885, VSP_019886; Note=No experimental confirmation available.;
Catalytic ActivityPhosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate.
DomainThe N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity). {ECO:0000250}.
Enzyme RegulationStimulated by cytosolic Ca(2+). {ECO:0000250}.
FunctionCalcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. {ECO:0000269|PubMed:15866882}.
SimilarityContains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
SimilarityContains 1 PLA2c domain. {ECO:0000255|PROSITE- ProRule:PRU00555}.
Subcellular LocationCytoplasm, cytosol {ECO:0000269|PubMed:15866882}. Lysosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Translocates to lysosomal membranes in a calcium-dependent fashion.
Tissue SpecificityPredominantly expressed in heart, skeletal muscle, testis and thyroid. Expressed at lower level in brain and stomach. {ECO:0000269|PubMed:15866882}.