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LMP001845

Record overview

LMPD IDLMP001845
Gene ID4836
SpeciesHomo sapiens (Human)
Gene NameN-myristoyltransferase 1
Gene SymbolNMT1
SynonymsNMT
Alternate namesglycylpeptide N-tetradecanoyltransferase 1; NMT 1; long form, NMT-L; alternative, short form NMT-S; type I N-myristoyltransferase; peptide N-myristoyltransferase 1; myristoyl-CoA:protein N-myristoyltransferase 1
Chromosome17
Map Location17q21.31
EC Number2.3.1.97
SummaryMyristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311) (Duronio et al., 1992 [PubMed 1570339]).[supplied by OMIM, Nov 2008]
OrthologsView orthologs and multiple alignments for NMT1

Proteins

glycylpeptide N-tetradecanoyltransferase 1
Refseq ID:NP_066565
Protein GI:10835073
UniProt ID:P30419
mRNA ID:NM_021079
Length:496
RefSeq Status:PROVISIONAL
MADESETAVKPPAPPLPQMMEGNGNGHEHCSDCENEEDNSYNRGGLSPANDTGAKKKKKKQKKKKEKGSETDSAQDQPVKMNSLPAERIQEIQKAIELFS
VGQGPAKTMEEASKRSYQFWDTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGFTWDALDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWA
LRPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEKKMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRS
LNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLLTRYLKQFHLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSF
YTLPSTIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGAEKVGLVLQ